The long QT syndrome (LQTS) is a rare inborn heart condition in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). These episodes may lead to palpitations, fainting and sudden death due to ventricular fibrillation. Episodes may be provoked by various stimuli, depending on the subtype of the condition.
The condition is so named because of the appearances of the electrocardiogram (ECG/EKG), on which there is prolongation of the QT interval. In some individuals the QT prolongation occurs only after the administration of certain medications.
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... The first documented case of Long QT syndrome was described in Leipzig by Meissner in 1856, where a deaf girl died after her teacher yelled at her ... before the ECG was invented, but is likely the first described case of Jervell and Lange-Nielsen syndrome ... Ward, in 1964, separately described the more common variant of Long QT syndrome with normal hearing, later called Romano-Ward syndrome ...
... The first case report in which the shortening of the QT interval by primidone was documented, published in the July 1980 issue of Annals of Internal Medicine, involved three patients, a 31-ye ... After the surgery, the QT-prolongation returned, so the phenytoin was doubled to 200 mg four times daily ... The primidone suppressed the fibrillations and lengthened the QT interval for two years and eight months in the patient ...
... The X-26 Frigate is the longest-lived of the X-plane programs ... The program included the X-26A Frigate sailplane and the motorized X-26B Quiet Thruster versions QT-2, QT-2PC, and QT-2PCII ...
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