Interleukin 21

Interleukin 21

Identifiers Symbols IL21; IL-21; Za11 External IDs OMIM: 605384 MGI: 1890474 HomoloGene: 11032 GeneCards: IL21 Gene

Gene Ontology
Molecular function cytokine activity
cytokine receptor binding
interleukin-2 receptor binding
Cellular component extracellular space
Biological process positive regulation of natural killer cell cytokine production
immune response
signal transduction
positive regulation of cell proliferation
positive regulation of B cell proliferation
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell differentiation
positive regulation of tissue remodeling
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of interferon-gamma biosynthetic process
positive regulation of natural killer cell mediated cytotoxicity
cell maturation
positive regulation of inflammatory response
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 59067 60505 Ensembl ENSG00000138684 ENSMUSG00000027718 UniProt Q9HBE4 Q9ES17 RefSeq (mRNA) NM_001207006.2 NM_021782.2 RefSeq (protein) NP_001193935.1 NP_068554.1 Location (UCSC) Chr 4:
123.53 – 123.54 Mb Chr 3:
37.22 – 37.23 Mb PubMed search

Interleukin-21 is a protein that in humans is encoded by the IL21 gene.

Interleukin 21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells.

Read more about Interleukin 21:  Gene, Tissue and Cell Distribution, Receptor

Other articles related to "interleukin 21, 21":

Interleukin 21 - Clinical Relevance - Role in Viral Infections
... IL-21 may be a critical factor in the control of persistent viral infections ... IL-21 (or IL-21R) knock-out mice infected with chronic LCMV (lymphocytic choriomeningitis virus) were not able to overcome chronic infection compared to normal mice ... Besides, these mice with impaired IL-21 signaling had more dramatic exhaustion of LCMV-specific CD8+ T cells, suggesting that IL-21 produced by CD4+ T cells is required for sustained CD8 ...