HLA A1-B8 Haplotype - Disease Associations - A1-B8 and Allergic Disease

A1-B8 and Allergic Disease

In allergic disease A1,B8 were found to associate with allergic reactions in new-borns. A1, B8 was found increased in children with bronchial asthma and low IgA. However, some of this reaction can be attributed to the linkage of the HLA A1-B8-DR3-DQ2 haplotype to the IgA-less phenotype. A firmer association was found with atopies. A1,B8 where found more frequently in hay fever complicated by asthma or atopia relative to just hay fever. Further asthmatic patients with negative skin tests tended toward higher A1,B8 serotypes.

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