Hedgehog Signaling

Some articles on signaling, hedgehog signaling, hedgehog:

Secreted Frizzled-related Protein 1 - Function - Wnt-dependent Signaling
... The Wnt signaling pathways are initiated by the binding of the Wnt ligand to the Fz receptor ... Several target genes of the Wnt signaling pathway, such as cyclin D1, are activated in a significant proportion of breast tumours ... chloride is widely used to mimic Wnt signaling ...
Patched - Role in Presence and Absence of Hedgehog Signaling
... Patched is part of a negative feedback mechanism for Hedgehog signaling that helps shape the spatial gradient of signaling activity across tissues ... In the absence of hedgehog, low levels of patched are sufficient to suppress activity of the signal transduction pathway ... When Hedgehog is present and binds to Patched, Patched somehow inhibits the activity of Smoothened, a G protein-coupled receptor, most of which is stored in membrane bound vesicles internally within the cell ...
Diet And Cancer - Chemotherapy
... Multiple oncogenic signaling pathways have been involved in the processes of cancer cell invasion and metastasis ... Among these signaling pathways, Wnt and Hedgehog signaling pathways are involved in the embryonic development, in the biology of cancer stem cells (CSCs) and in the acquisition of ... to their ability to attack CSCs or EMT-type cells by altering the Wnt and Hedgehog signaling pathways ...
Hedgehog Signaling Pathway - Vertebrates - Human Disease
... Disruption of hedgehog signaling during embryonic development, through either deleterious mutation or consumption of teratogens by the gestating mother, can lead to severe. 200 spontaneous abortions in humans and is commonly linked to mutations in genes involved in the hedgehog pathway, including SHH and PTCH ... Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, mammary gland, prostate ...