Glycerol-3-phosphate Dehydrogenase

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (aka glycerone phosphate, outdated) to sn-glycerol 3-phosphate.

Glycerol-3-phosphate dehydrogenase serves as a major link between carbohydrate metabolism and lipid metabolism. It is also a major contributor of electrons to the electron transport chain in the mitochondria.

Older terms for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase (alphaGPDH) and glycerolphosphate dehydrogenase (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase (GAPDH), whose substrate is an aldehyde not an alcohol.

Read more about Glycerol-3-phosphate Dehydrogenase:  Metabolic Function, Reaction, Variants, Glycerol-3-phosphate Shuttle, Role in Disease, Structure

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Glycerol-3-phosphate Dehydrogenase - Structure
... Glycerol-3-phosphate dehydrogenase consists of two protein domains ... The N-terminal domain is an NAD-binding domain, and the C-terminus acts as a substrate-binding domain ...