Gastric Antral Vascular Ectasia - Etiology or Pathogenesis

Etiology or Pathogenesis

The literature, from 1953 through 2010, often cited that the etiology or pathogenesis of watermelon disease are unknown.

Gender has some relationship to the etiology. 65% of patients with both cirrhosis and GAVE are male, but a total of 30% have both conditions. The causal connection between cirrhosis and GAVE has not been proven.

A connective tissue disease has been suspected in some cases.

Autoimmunity may have something to do with it, as 25% of all sclerosis patients who had a certain anti-RNA marker have GAVE. RNA autoimmunity has been suspected as a cause or marker since at least 1996.

One theory current since the 1990s focuses on a history of prolapse of the stomach into the small intestine.

Gastrin levels may indicate a hormonal connection. This may be due to a "vasoactive intestinal peptide and 5-hydroxy-tryptamine…".

It is also possible that infection by H. pylori can cause it.

Read more about this topic:  Gastric Antral Vascular Ectasia