Fringe Genes

Fringe genes are important in the workings of the notch signaling pathway.

In Drosophila melanogaster (the fruit fly) the fringe gene (fng) was identified as part of the notch mechanism. Later based on similarity, the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG) genes were identified in mammals.

Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases (GlcNAcT) glycosyltransferases.

The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.

The mouse and human Fringe family members map to three different chromosomes

  • Mfng maps to mouse Chr 15 and to human Chr 22
  • Lfng maps to mouse Chr 5, and human Chr 7
  • Rfng maps to mouse Chr 11, and human Chr 17

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    A lake is the landscape’s most beautiful and expressive feature. It is earth’s eye; looking into which the beholder measures the depth of his own nature. The fluviatile trees next the shore are the slender eyelashes which fringe it, and the wooded hills and cliffs around are its overhanging brows.
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