Doxycycline - Antiprotozoal


It is used in prophylaxis against malaria. It should not be used alone for initial treatment of malaria, even when the parasite is doxycycline-sensitive, because the antimalarial effect of doxycycline is delayed. This delay is related to its mechanism of action, which is to specifically impair the progeny of the apicoplast genes, resulting in their abnormal cell division.

It can be used in a treatment plan in combination with other agents, such as quinine.

Read more about this topic:  Doxycycline

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Peganum Harmala - Medicinal Uses - Antiprotozoal
... One of the compounds found in P ... harmala, vasicine (peganine), has been found to be safe and effective against Leishmania donovani, a protozoan parasite that can cause potentially fatal visceral leishmaniasis ...