Identifiers Symbols DNMT3A; DNMT3A2; M.HsaIIIA External IDs OMIM: 602769 MGI: 1261827 HomoloGene: 7294 ChEMBL: 1992 GeneCards: DNMT3A Gene EC number

Gene Ontology
Molecular function DNA binding
chromatin binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
unmethylated CpG binding
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Cellular component chromosome, centromeric region
nuclear heterochromatin
nuclear matrix
Biological process negative regulation of transcription from RNA polymerase II promoter
DNA methylation
methylation-dependent chromatin silencing
regulation of gene expression by genetic imprinting
DNA methylation on cytosine within a CG sequence
DNA methylation involved in embryo development
DNA methylation involved in gamete generation
hypermethylation of CpG island
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
cellular response to amino acid stimulus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1788 13435 Ensembl ENSG00000119772 ENSMUSG00000020661 UniProt Q9Y6K1 O88508 RefSeq (mRNA) NM_022552 NM_001271753 RefSeq (protein) NP_072046 NP_001258682 Location (UCSC) Chr 2:
25.46 – 25.57 Mb Chr 12:
3.81 – 3.91 Mb PubMed search

DNA (cytosine-5)-methyltransferase 3A is an enzyme that in humans is encoded by the DNMT3A gene.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than the maintenance of existing methylated sites. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Read more about DNMT3A:  Clinical Relevance, Interactions

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DNMT3A - Interactions
... DNMT3A has been shown to interact with ZNF238, HDAC1, Myc, Protein inhibitor of activated STAT2, DNMT1, DNMT3B, PIAS1, UBE2I and SUV39H1 ...