Diabetic Ulcer Fibroblasts

Diabetic Foot Ulcer - Pathophysiology - Altered Metabolism
... Diabetes mellitus is a metabolic disorder and hence the defects observed in diabetic wound healing are thought to be the result of altered protein and lipid metabolism and thereby abnormal granulation tissue ... Thus, nitric oxide increases fibroblast proliferation and thereby collagen production in wound healing ... Thus, diabetic patients exhibit reduced ability to generate nitric oxide from L-arginine ...