Ciliary Neurotrophic Factor

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.

The protein encoded by this gene is a polypeptide hormone and nerve growth factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations including astrocytes. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone forming cells, osteoblasts.

Read more about Ciliary Neurotrophic FactorInteractions

Other articles related to "ciliary neurotrophic factor, factor":

Ciliary Neurotrophic Factor - Interactions
... Ciliary neurotrophic factor has been shown to interact with Interleukin-6 receptor. ...
Ciliary Neurotrophic Factor Receptor
... The ciliary neurotrophic factor receptor also known as CNTFR binds the ciliary neurotrophic factor ...
Leukemia Inhibitory Factor Receptor
... LIFR Gene Gene Ontology Molecular function • ciliary neurotrophic factor receptor activity • leukemia inhibitory factor receptor activity • oncostatin-M receptor activity ... The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo ... of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin ...

Famous quotes containing the word factor:

    Children of the middle years do not do their learning unaffected by attendant feelings of interest, boredom, success, failure, chagrin, joy, humiliation, pleasure, distress and delight. They are whole children responding in a total way, and what they feel is a constant factor that can be constructive or destructive in any learning situation.
    Dorothy H. Cohen (20th century)