CD117

CD117

Identifiers Symbols KIT; C-Kit; CD117; PBT; SCFR External IDs OMIM: 164920 MGI: 96677 HomoloGene: 187 ChEMBL: 1936 GeneCards: KIT Gene EC number 2.7.10.1

Gene Ontology
Molecular function protease binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
stem cell factor receptor activity
protein binding
ATP binding
cytokine binding
protein homodimerization activity
metal ion binding
Cellular component extracellular space
nucleus
cytoplasm
plasma membrane
external side of plasma membrane
integral to membrane
Biological process activation of MAPK activity
ovarian follicle development
myeloid progenitor cell differentiation
lymphoid progenitor cell differentiation
immature B cell differentiation
dendritic cell cytokine production
mast cell chemotaxis
glycosphingolipid metabolic process
inflammatory response
signal transduction
intracellular protein kinase cascade
spermatogenesis
spermatid development
positive regulation of cell proliferation
regulation of cell shape
male gonad development
response to radiation
positive regulation of gene expression
positive regulation of phospholipase C activity
positive regulation of phosphatidylinositol 3-kinase cascade
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
stem cell maintenance
signal transduction by phosphorylation
lamellipodium assembly
hemopoiesis
T cell differentiation
erythrocyte differentiation
melanocyte differentiation
actin cytoskeleton reorganization
mast cell cytokine production
embryonic hemopoiesis
germ cell programmed cell death
megakaryocyte development
Fc receptor signaling pathway
Kit signaling pathway
erythropoietin-mediated signaling pathway
regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of programmed cell death
mast cell degranulation
positive regulation of MAPK cascade
pigmentation
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of JAK-STAT cascade
protein autophosphorylation
regulation of developmental pigmentation
digestive tract development
stem cell differentiation
detection of mechanical stimulus involved in sensory perception of sound
positive regulation of sequence-specific DNA binding transcription factor activity
cell chemotaxis
mast cell differentiation
mast cell proliferation
cellular response to thyroid hormone stimulus
melanocyte migration
melanocyte adhesion
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3815 16590 Ensembl ENSG00000157404 ENSMUSG00000005672 UniProt P10721 P05532 RefSeq (mRNA) NM_000222.2 NM_001122733.1 RefSeq (protein) NP_000213.1 NP_001116205.1 Location (UCSC) Chr 4:
55.52 – 55.61 Mb Chr 5:
75.57 – 75.66 Mb PubMed search

Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit.

Read more about CD117:  Cell Surface Marker, Function, Mobilization, Role in Cancer, Diagnostic Relevance, Interactions

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CD117 - Interactions
... CD117 has been shown to interact with APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6, SRC, and TEC ...