Carnitine O-acetyltransferase

Carnitine O-acetyltransferase

In enzymology, a carnitine O-acetyltransferase (CRAT, or CAT) (EC is an enzyme that catalyzes the chemical reaction

acetyl-CoA + carnitine CoA + O-acetylcarnitine

Thus, the two substrates of this enzyme are acetyl-CoA and carnitine, whereas its two products are CoA and O-acetylcarnitine.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:carnitine O-acetyltransferase. Other names in common use include acetyl-CoA-carnitine O-acetyltransferase, acetylcarnitine transferase, carnitine acetyl coenzyme A transferase, carnitine acetylase, carnitine acetyltransferase, carnitine-acetyl-CoA transferase, and CATC. This enzyme participates in alanine and aspartate metabolism.

Read more about Carnitine O-acetyltransferaseEnzyme Structure, Enzyme Mechanism, Biological Function, Disease Relevance

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Carnitine O-acetyltransferase - Disease Relevance
... Reduced CRAT activity can be found in individuals suffering from Alzheimer’s disease ... CRAT and its family of enzymes have great potential as targets for developing therapeutic treatments for Type 2 diabetes and other diseases. ...