Antipolo (officially: City of Antipolo, Filipino: Lungsod ng Antipolo) is a city in the Philippines located in the province of Rizal; about 25 kilometres (16 mi) east of Manila. It is the largest city in the Calabarzon Region. It is also the seventh most populous city in the country with a population of 633,971 in 2007.

It was converted from a municipality into a component city of Rizal Province on April 4, 1998 under Republic Act No. 8508. A new provincial capitol building was inaugurated in the city in March 2009 to replace the old capitol in Pasig which has long been outside the jurisdiction of Rizal Province; after Pasig was included in Metro Manila in 1975. With the transfer of the provincial government to Antipolo, it is highly favored to be officially designated as the new capital of the province. On March 14, 2011, Antipolo was declared a "highly-urbanized city" by President Benigno Aquino; such proclamation however still needs to be ratified in a plebiscite.

The city is popular for being a pilgrimage site. It prides itself as the "Pilgrimage Capital of the Philippines." The Marian image of the Our Lady of Peace and Good Voyage or the Virgin of Antipolo, which was brought in from Mexico in 1626, and enshrined in the Antipolo Cathedral has a continuous following among Filipino Catholics since the Spanish era. A popular custom of pilgrims to the Virgin of Antipolo is the trek going to its shrine on the eves of Good Friday and May 1, from various locations in Rizal Province and Metro Manila. Some pilgrims would begin the trek from Quiapo Church in Downtown Manila following the procession of the image. There is also an existing custom to have new cars blessed at the church in the belief that this will ensure the safety of the car and its passengers.

Its higher elevation than that of Metro Manila affords it a scenic view of the metropolis, especially at night. Its locally grown mangoes and cashews are popular among tourists, as well as suman – a local delicacy made out of glutinous rice. The Hinulugan Taktak National Park, which was once a popular summer get-away is being restored to become again one of the city's primary attractions.

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