Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.

The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.

Read more about Androgen Receptor:  Interactions

Other articles related to "androgen, androgen receptor, receptor":

Bicalutamide - Description and Mechanism of Action
... Bicalutamide is an oral non-steroidal anti-androgen with the empirical formula C18H14F4N2O4S and is an off-white powder that is practically insoluble in water ... Bicalutamide acts as a pure anti-androgen by binding to the androgen receptor (AR) and preventing the activation of the AR and subsequent upregulation ... In addition, bicalutamide accelerates the degradation of the androgen receptor ...
PIAS1
... ubiquitin protein ligase binding • androgen receptor binding Cellular component • nucleus • nucleoplasm • PML body • nuclear speck ... II/DEAD box polypeptide 21, and interacts with androgen receptor (AR) ... It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis ...
Spironolactone - Uses - As An Antiandrogen
... Spironolactone is a potent antagonist of the androgen receptor as well as an inhibitor of androgen production ... it is frequently used to treat a variety of cosmetic conditions in which androgen hormones such as testosterone and dihydrotestosterone (DHT) play a role, including hirsutism, androgenic alopecia, acne ... There are very few available options for androgen receptor antagonist drug therapy ...
Selective Androgen Receptor Modulator
... Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands ... The name follows the terminology currently used for similar molecules targeting the estrogen receptor, "selective estrogen receptor modulators," such as Tamoxifen ...
Androgen Receptor - Interactions
... Androgen receptor has been shown to interact with AKT1, BAG1, Beta-catenin, BRCA1, C-jun, Calmodulin 1, Caveolin 1, CDK9, COX5B, CREB-binding protein, Cyclin D1, Cyclin-dependent kinase 7, Death ...

Famous quotes containing the word receptor:

    The disinterest [of my two great-aunts] in anything that had to do with high society was such that their sense of hearing ... put to rest its receptor organs and allowed them to suffer the true beginnings of atrophy.
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