Acetylserotonin O-methyltransferase

Acetylserotonin O-methyltransferase

Identifiers Symbols ASMT; ASMTY; HIOMT; HIOMTY External IDs OMIM: 402500 MGI: 96090 HomoloGene: 48261 GeneCards: ASMT Gene EC number 2.1.1.4

Gene Ontology
Molecular function O-methyltransferase activity
acetylserotonin O-methyltransferase activity
Cellular component cytosol
Biological process translation
melatonin biosynthetic process
cellular nitrogen compound metabolic process
small molecule metabolic process
indolalkylamine biosynthetic process
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 438 n/a Ensembl ENSG00000196433 n/a UniProt P46597 n/a RefSeq (mRNA) NM_001171038.1 n/a RefSeq (protein) NP_001164509.1 n/a Location (UCSC) Chr X:
1.73 – 1.76 Mb n/a PubMed search n/a

N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.

In humans the ASMT enzyme is encoded by the ASMT gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.

Read more about Acetylserotonin O-methyltransferaseStructure and Gene Location, Class of Enzyme and Function, Synonyms, Organisms, Amino Acid Sequences, Reactions Catalyzed, Linkage Analysis, Additional Research

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