|Molecular function||• O-methyltransferase activity
• acetylserotonin O-methyltransferase activity
|Cellular component||• cytosol
|Biological process||• translation
• melatonin biosynthetic process
• cellular nitrogen compound metabolic process
• small molecule metabolic process
• indolalkylamine biosynthetic process
|Sources: Amigo / QuickGO|
1.73 – 1.76 Mb
N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.
In humans the ASMT enzyme is encoded by the ASMT gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.
Read more about Acetylserotonin O-methyltransferase: Structure and Gene Location, Class of Enzyme and Function, Synonyms, Organisms, Amino Acid Sequences, Reactions Catalyzed, Linkage Analysis, Additional Research
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