Zangpo is a surname. Notable people with the surname include:
- Karma Thubten Trinlay Gyurme Pal Zangpo, tulku in the Kagyu school of Tibetan Buddhism
- Rinchen Zangpo (958–1055), principal translator of Sanskrit Buddhist texts into Tibetan
- Rongzom Chokyi Zangpo, scholar of the Nyingma school of Tibetan Buddhism
- Takna Jigme Zangpo (born 1926), spent thirty-seven years in a Chinese prison in Lhasa, Tibet as a political prisoner
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