Yerkes is a surname. Notable people with the surname include:
- Charles Yerkes (1837–1905), American financier who played a major part in developing mass-transit systems in Chicago and London
- Robert Yerkes (1876–1956), American psychologist, ethologist, and primatologist
- Steve Yerkes (1888–1971), American baseball player
Yerkes may also refer to:
- Yerkes Observatory, an astronomical observatory of the University of Chicago
- Yerkes luminosity classification of stars
- Yerkes scheme of galaxy morphological classification
- Yerkes National Primate Research Center, one of eight national primate research centers funded by the National Institutes of Health, located in Atlanta, Georgia at Emory University
- Yerkes–Dodson law, an empirical relationship between arousal and performance first noted by Robert M. Yerkes and John Dillingham Dodson
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