Identifiers Symbols YARS; CMTDIC; TYRRS; YRS; YTS External IDs OMIM: 603623 MGI: 2147627 HomoloGene: 2730 ChEMBL: 3179 GeneCards: YARS Gene EC number

Gene Ontology
Molecular function tRNA binding
tyrosine-tRNA ligase activity
signal transducer activity
interleukin-8 receptor binding
ATP binding
Cellular component extracellular space
Biological process tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation
apoptotic process
signal transduction
gene expression
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8565 107271 Ensembl ENSG00000134684 ENSMUSG00000028811 UniProt P54577 Q91WQ3 RefSeq (mRNA) NM_003680 NM_134151 RefSeq (protein) NP_003671 NP_598912 Location (UCSC) Chr 1:
33.24 – 33.28 Mb Chr 4:
129.19 – 129.22 Mb PubMed search

Tyrosyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the YARS gene.

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.

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