|Molecular function||• transcription coactivator activity
• transcription corepressor activity
• protein binding
• zinc ion binding
• metal ion binding
|Cellular component||• nucleus
|Biological process||• transcription, DNA-dependent
• negative regulation of transcription, DNA-dependent
• positive regulation of transcription, DNA-dependent
|Sources: Amigo / QuickGO|
42.55 – 42.63 Mb
93.28 – 93.34 Mb
YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.