Coeliac Disease
Coeliac disease ( /ˈsiːli.æk/; spelled celiac disease in North America and often celiac sprue) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward. Symptoms include chronic diarrhoea, failure to thrive (in children), and fatigue, but these may be absent, and symptoms in other organ systems have been described.
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Some articles on coeliac disease:
... Gee gave the first modern-day description of coeliac disease in a lecture at the Hospital for Sick Children, Great Ormond Street in 1887 ... Signs of the disease are yielded by the fæces being loose, not formed, but not watery more bulky than the food taken would seem to account for pale in colour ... Gee acknowledges earlier findings and terms for the disease and adopts the same term as Aretaeus ...
... typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and dermatitis herpetiformis in 1976 ... the haplotype it became possible to identify the genetic risk even though disease causing genes, a DQ2 haplotype, was 1.3 million nucleotides away ... Further information HLA-DQ2 in coeliac disease and HLA-DQ2.5 in gluten immunochemistry Aside from the highly studied link between DQ2.5 and coeliac ...
... Antibodies to ganglioside are found to be elevated in coeliac disease ... Recent studies show that gliadin can cross-link to gangliosides in a transglutaminase independent manner, indicating that gliadin specific T-cell could present these antigens to the immune system ...
... The release of IL15 is a major factor in coeliac disease as IL15 has been found to attract intraepithelial lymphocytes (IEL) that characterize Marsh ... peptide activation of T-cells in celiac disease is strange ... In addition, innate immunity to IRP peptide is involved in coeliac disease, dermatitis herpetiformis and possibly juvenile diabetes ...
... Crescent in Western Asia, and it is likely that coeliac disease did not occur before this time ... His "Cœliac Affection" (coeliac from Greek κοιλιακός koiliakos, "abdominal") gained the attention of Western medicine when Francis Adams presented a translation of Aretaeus's work at the Sydenham Society in ... as loose stools that were white, malodorous and flatulent, and the disease was intractable and liable to periodic return ...
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