What is cisapride?

Cisapride

Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited because of side effects.

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Some articles on cisapride:

Hyperacidity - Treatment
... of up to 50%, but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now only available as an investigational agent) due to ... one trial suggests potential benefit over placebo and another shows equivalence with cisapride ... This German-made phytopharmaceutical was found to be equivalent to cisapride and significantly superior to metoclopramide at reducing the symptoms of functional dyspepsia over a four-w ...
Cisapride - Pharmacology and Mechanism of Action
... that increases gastrointestinal motility, cisapride acts as a selective serotonin agonist in the 5-HT 4 receptor subtype ... Cisapride also relieves constipation-like symptoms by indirectly stimulating the release of acetylcholine in the muscarinic receptors ...
Dyspepsia - Treatment
... to come to this conclusion used the drug cisapride which has since been removed from the market (now only available as an investigational agent) due to serious ... some value, as one trial suggests potential benefit over placebo and another shows equivalence with cisapride ... was found to be equivalent to cisapride and significantly superior to metoclopramide at reducing the symptoms of functional dyspepsia over a four week period ...
Itopride - Adverse Drug Reactions - Cardiac Studies
... Itopride belongs to the same benzamide group as cisapride, a drug which was found to affect QT interval and possibly predispose those using it to cardiac arrhythmias ... This resulted in cisapride being voluntarily removed from the U.S ... These studies indicated that unlike cisapride, itopride was devoid of the potential to cause prolongation of the QT interval and posed no known risk of ...