What is asparaginase?

  • (noun): Antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia.
    Synonyms: Elspar


Asparaginase (EC is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. Asparaginases are naturally occurring enzymes expressed and produced by microorganisms.

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Some articles on asparaginase:

... Gene Ontology Molecular function • N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity • asparaginase activity • beta-aspartyl-peptidase activity Cellular ...
Asparaginase - History
... The discovery and development of asparaginase as an anti-cancer drug began in 1953, when scientists first observed that lymphomas in rat and mice regressed after treatment with guinea pig serum ... it is not the serum itself which provoke the tumour regression, but rather the enzyme asparaginase ... After researches comparing different kinds of asparaginases, the one derived from Escherichia coli and Erwinia chrysanthemi turned out to have the best anti-cancer ...