Voltage-dependent Calcium Channel - Channel Subunits

Channel Subunits

There are several different kinds of high-voltage-gated calcium channels (HVGCCs). They are structurally homologous among varying types; they are all similar, but not structurally identical. In the laboratory, it is possible to tell them apart by studying their physiological roles and/or inhibition by specific toxins. High-voltage-gated calcium channels include the neural N-type channel blocked by ω-conotoxinGVIA, the R-type channel (R stands for Resistant to the other blockers and toxins, except SNX-482) involved in poorly defined processes in the brain, the closely related P/Q-type channel blocked by ω-agatoxins, and the dihydropyridine-sensitive L-type channels responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle and for hormone secretion in endocrine cells.

Current Type 1,4-dihydropyridine sensitivity (DHP) ω-conotoxin sensitivity (ω-CTX) ω-agatoxin sensitivity (ω-AGA)
L-type blocks resistant resistant
N-type resistant blocks resistant
P/Q-type resistant resistant blocks
R-type resistant resistant resistant

Read more about this topic:  Voltage-dependent Calcium Channel

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Voltage-dependent Calcium Channel - Channel Subunits - Muscle Physiology
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