Tryptophan 2,3-dioxygenase - Introduction


This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. This family of enzymes includes tryptophan 2,3-dioxygenase (TDO, also known as tryptophan oxygenase and L-tryptophan pyrrolase) and indoleamine 2,3-dioxygenase (IDO, also known as tryptophan pyrrolase). These two enzymes are oxidoreductase enzymes that contain one noncovalently bound iron–protoporphyrin IX per monomer. These enzymes catalyze the dioxygenation of L-tryptophan (L-Trp) to N-formyl-L-kynurenine in the first and rate-limiting step of the kynurenine pathway.

The same family of enzymes also includes sIDO from Shewanella oneidensis and PrnB, the second enzyme in the pyrrolnitrin biosynthesis pathway from Pseudomonas fluorescens, although dioxygenase activity has not been demonstrated for either as yet. Recently, a new enzyme with the ability to catalyze L-tryptophan dioxygenation, INDOL1, was identified.

Tryptophan 2,3-dioxygenase was initially discovered in the 1930s and is found in both eukaryotes (human, rat, and rabbit) and prokaryotes (Xanthomonas campestris, and P. fluorescens) Expression of tryptophan 2,3-dioxygenase in mammals is normally restricted to the liver, but it has been identified in the brain and epididymis of some species, and, in some tissues, its production can be induced in response to stimuli.

Read more about this topic:  Tryptophan 2,3-dioxygenase

Other articles related to "introduction":

Introduction To Metaphysics
... An Introduction to Metaphysics (Introduction à la Métaphysique) is a 1903 essay by Henri Bergson that explores the concept of reality ...
Introduction - Music - Songs and Tracks
... Introduction", by Chicago from The Chicago Transit Authority "Introduction", by Hood from Outside Closer "Introduction", by Kajagoogoo from White Feathers "Introduction", by Mike ...
John Frame (theologian) - Selected Works
... Introduction to Presuppositional Apologetics Part 2 ... Van Til The Theologian, 1976 ISBN 0-916034-02-X Medical Ethics, 1988 ISBN 0-87552-261-0 Perspectives on the Word of God An Introduction to ...
China Miéville - Bibliography - Nonfiction - Introductions To Fiction By Other Authors
... The Borribles An Introduction, 2001 ... Things That Never Happen An Introduction, 2002 ... Wizardry and Wild An Introduction, 2004 ...

Famous quotes containing the word introduction:

    For the introduction of a new kind of music must be shunned as imperiling the whole state; since styles of music are never disturbed without affecting the most important political institutions.
    Plato (c. 427–347 B.C.)

    Do you suppose I could buy back my introduction to you?
    S.J. Perelman, U.S. screenwriter, Arthur Sheekman, Will Johnstone, and Norman Z. McLeod. Groucho Marx, Monkey Business, a wisecrack made to his fellow stowaway Chico Marx (1931)

    We used chamber-pots a good deal.... My mother ... loved to repeat: “When did the queen reign over China?” This whimsical and harmless scatological pun was my first introduction to the wonderful world of verbal transformations, and also a first perception that a joke need not be funny to give pleasure.
    Angela Carter (1940–1992)