Genetic Defects
Most testicular germ cell tumors have too many chromosomes, and most often they are triploid to tetraploid. An isochromosome 12p (the short arm of chromosome 12 on both sides of the same centromere) is present in about 80% of the testicular cancers, and also the other cancers usually have extra material from this chromosome arm through other mechanisms of genomic amplification.
Read more about this topic: Testicular Cancer
Famous quotes containing the words genetic and/or defects:
“Nature, we are starting to realize, is every bit as important as nurture. Genetic influences, brain chemistry, and neurological development contribute strongly to who we are as children and what we become as adults. For example, tendencies to excessive worrying or timidity, leadership qualities, risk taking, obedience to authority, all appear to have a constitutional aspect.”
—Stanley Turecki (20th century)
“The East is the hearthside of America. Like any home, therefore, it has the defects of its virtues. Because it is a long-lived-in house, it bursts its seams, is inconvenient, needs constant refurbishing. And some of the family resources have been spent. To attain the privacy that grown-up people find so desirable, Easterners live a harder life than people elsewhere. Today it is we and not the frontiersman who must be rugged to survive.”
—Phyllis McGinley (1905–1978)