Synaptic Gating

Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).

Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.

Read more about Synaptic GatingGated Synapse Model, Permissive Gating, Current and Future Research

Other articles related to "synaptic gating, gating":

Synaptic Gating - Permissive Gating
... an action potential, and consequently the release of neurotransmitters, occurs by this gating mechanism ... In synaptic gating, in order for an action potential to occur, there must be more than one input to produce a single output in the neuron being gated ... An example of this type of gating may occur in the nucleus accumbens ...
Synaptic Gating - Current and Future Research
... There appear to be three different types of gating circuits – one that is controlled by the cortex, one that is controlled by the association nuclei in the thalamus, and one that is controlled ... Strong evidence has concluded that gating from thalamus impacts the prefrontal cortex response from the hippocampus ... all at once? These are the questions at the heart of synaptic gating in the future ...