SVIL

SVIL

Identifiers Symbols SVIL; DKFZp686A17191 External IDs OMIM: 604126 MGI: 2147319 HomoloGene: 25090 GeneCards: SVIL Gene

Gene Ontology
Molecular function	• actin filament binding
Cellular component	• podosome • nucleus • cytoplasm • plasma membrane • actin cytoskeleton • cell junction • costamere • invadopodium
Biological process	• cytoskeleton organization • skeletal muscle tissue development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6840 225115 Ensembl ENSG00000197321 ENSMUSG00000024236 UniProt O95425 Q8K4L3 RefSeq (mRNA) NM_003174 NM_153153 RefSeq (protein) NP_003165 NP_694793 Location (UCSC) Chr 10:
29.75 – 30.03 Mb Chr 18:
4.92 – 5.12 Mb PubMed search

Supervillin is a protein that in humans is encoded by the SVIL gene.

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.