Sirna

Sirna Therapeutics
... Sirna Therapeutics, Inc ... Sirna's development pipeline includes several small interfering RNA (siRNA) drugs, thought to stably silence the expression of specific disease-related genes ... Sirna's clinical trial of an siRNA-based treatment for age-related macular degeneration is the first such trial for an siRNA drug ...

Trans-acting Si RNA
... Trans-acting siRNA (abbreviated "TAS", "ta-siRNA" or sometimes "tasiRNA") is a form of small interfering RNA (siRNA) that represses gene expression through post-transcriptional gene silencing in land plants ... Ta-siRNAs are transcribed from the genome to form a polyadenylated, double-stranded segment of RNA that gets processed further, resulting in a segment ... ta-siRNAs are termed siRNA because they undergo similar processing and both arise from double-stranded RNA (dsRNA) ...

Rasi RNA - RasiRNA Are Distinct From Other RNAi Pathways
... distinct from other RNAi pathways such as microRNA (miRNA) and small interfering RNA (siRNA) as well as from piRNA ... Unlike miRNA and siRNA which function through the Ago Argonaute protein subfamily, RasiRNA function through the Piwi Argonaute protein subfamily ... Contrary to miRNAs which are 21-23 nucleotides in length, siRNAs which are 20-25 nucleotides in length, and piRNAs which are 24-31 nucleotides in length, rasiRNAs are 24-29 nucleotides in length ...

Cell-penetrating Peptide - Applications of CPPs - CPP Mediated Delivery of Nucleic Acids - New Substrate Design For SiRNA Delivery
... siRNA cell delivery represent a valuable tool for treatment of cancer disease, viral infections and genetic disorders ... of cargo molecules and CPPs, which does not provide efficient protection of siRNA molecules in vivo thus results reported in literature are not consistent ... of the surface that represent the lowest energy and it is able to form complexes with siRNA at different molar ratio varying from 11 to 801 ...