Sherlock may be:
- an English surname.
- William Sherlock, 1641–1707, English church leader
- Thomas Sherlock, 1678–1761 (son of William), English bishop
- William Sherlock (cricketer), 1881–1937
- Richard Sherlock (b. 1983), cricketer
- James Sherlock (b.1983), pianist
- Sherlock Holmes, a fictional detective created by Arthur Conan Doyle
- Sherlock Holmes (disambiguation), various adaptations of the Sherlock Holmes stories
- Sherlock (TV series), a BBC TV series that started in 2010, placing the Sherlock Holmes stories in current time
- Sherlock Hemlock, a Muppet from the TV show Sesame Street
- Sherlock (software), search software for Apple Macintosh
- Sherlock (video game), a 1984 text adventure by Melbourne House
- Music
- Sherlock (EP), by Shinee
- toponymy
- Sherlock, South Australia
- Sherlock, Western Australia
- Sherlock Township, Finney County, Kansas