PRF is an acronym and can stand for:
- Platelet Rich Fibrin, A combination of platelets and fibrin used to regenerate tissue
- PRF-3, the call letters of the now defunct TV Tupi, Brazil's first television station
- Pain Relief Foundation
- Primitive recursive function - a class of functions which form an important building block on the way to a full formalization of computability
- Pseudorandom function - in cryptography to refer to a function with values seemingly chosen randomly within its range
- Pulse repetition frequency - a characteristic of a radar transmitter
- Pennsylvania Renaissance Faire
- Passer rating formula, a system used to rate passers in American football
- Pontine reticular formation
- Polícia Rodoviária Federal is the Federal Highway Police of Brazil
- Pacific Ring of Fire, a ring of volcanoes circuling the Pacific Ocean
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