| Gene Ontology | |
|---|---|
| Molecular function | • cyclic-nucleotide phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • calcium channel activity • protein binding • drug binding • cAMP binding • cGMP binding • TPR domain binding • protein homodimerization activity • metal ion binding |
| Cellular component | • nucleus • cytoplasm • mitochondrial matrix • endoplasmic reticulum • Golgi apparatus • cytosol • plasma membrane • axon • dendrite • presynaptic membrane • perinuclear region of cytoplasm |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • cAMP catabolic process • protein targeting to mitochondrion • blood coagulation • metabolic process • cAMP-mediated signaling • cGMP-mediated signaling • monocyte differentiation • negative regulation of cAMP biosynthetic process • negative regulation of protein import into nucleus, translocation • cellular response to drug • cellular response to macrophage colony-stimulating factor stimulus • negative regulation of vascular permeability • positive regulation of vascular permeability • cGMP catabolic process • positive regulation of inflammatory response • establishment of endothelial barrier • calcium ion transmembrane transport • cellular response to mechanical stimulus • cellular response to cGMP • cellular response to transforming growth factor beta stimulus • cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| Sources: Amigo / QuickGO | |
72.29 – 72.39 Mb
101.42 – 101.51 Mb
cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.