Palafox may refer to:
- Palafoxia, a Genus of flowering plants from the sunflower family
- Antonio Palafox, a Mexican tennis player
- José de Palafox y Melzi, Duke of Saragossa, a Spanish general
- Juan de Palafox y Mendoza (1600 – 1659), a Spanish bishop, politician and writer in colonial Mexico
- Manuel Palafox, a Mexican politician