P-glycoprotein

P-glycoprotein

Identifiers Symbols ABCB1; ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 External IDs OMIM: 171050 MGI: 97570 HomoloGene: 55496 ChEMBL: 4302 GeneCards: ABCB1 Gene EC number 3.6.3.44

Gene Ontology
Molecular function	• transporter activity • protein binding • ATP binding • xenobiotic-transporting ATPase activity • ATPase activity, coupled to transmembrane movement of substances
Cellular component	• Golgi membrane • plasma membrane • cell surface • membrane • integral to membrane • apical plasma membrane • intercellular canaliculus
Biological process	• G2/M transition of mitotic cell cycle • transport • drug transmembrane transport • response to drug • small molecule metabolic process • transmembrane transport • stem cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5243 18671 Ensembl ENSG00000085563 ENSMUSG00000040584 UniProt P08183 P21447 RefSeq (mRNA) NM_000927.4 NM_011076.2 RefSeq (protein) NP_000918.2 NP_035206.2 Location (UCSC) Chr 7:
87.13 – 87.34 Mb Chr 5:
8.66 – 8.75 Mb PubMed search

ABCB1 at EBI Gene Expression Atlas
ABCB1 is differentially expressed in 97 experiments : 26 organism parts: kidney, bone marrow, ...; 29 disease states: normal, glioblastoma, ...; 30 cell types, 22 cell lines, 11 compound treatments and 16 other conditions.
Factor Value	Factor	Up/Down
Legend: - number of studies the gene is up/down in
Normal	Disease state	10/3
None	Compound treatment	3/0
Stromal cell	Cell type	1/2
Kidney	Cell type	2/0
MDA-MB-231	Cell line	0/2
Glioblastoma	Disease state	0/2
Epithelial cell	Cell type	0/2
HeLa	Cell line	0/2
Primary	Disease staging	2/0
Bone marrow	Organism part	0/2
ABCB1 expression data in ATLAS

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.

Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.