Identifiers Symbols ABCB1; ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 External IDs OMIM: 171050 MGI: 97570 HomoloGene: 55496 ChEMBL: 4302 GeneCards: ABCB1 Gene EC number

Gene Ontology
Molecular function transporter activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
ATPase activity, coupled to transmembrane movement of substances
Cellular component Golgi membrane
plasma membrane
cell surface
integral to membrane
apical plasma membrane
intercellular canaliculus
Biological process G2/M transition of mitotic cell cycle
drug transmembrane transport
response to drug
small molecule metabolic process
transmembrane transport
stem cell proliferation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5243 18671 Ensembl ENSG00000085563 ENSMUSG00000040584 UniProt P08183 P21447 RefSeq (mRNA) NM_000927.4 NM_011076.2 RefSeq (protein) NP_000918.2 NP_035206.2 Location (UCSC) Chr 7:
87.13 – 87.34 Mb Chr 5:
8.66 – 8.75 Mb PubMed search
ABCB1 at EBI Gene Expression Atlas
ABCB1 is differentially expressed in 97 experiments : 26 organism parts: kidney, bone marrow, ...; 29 disease states: normal, glioblastoma, ...; 30 cell types, 22 cell lines, 11 compound treatments and 16 other conditions.
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state 10/3
None Compound treatment 3/0
Stromal cell Cell type 1/2
Kidney Cell type 2/0
MDA-MB-231 Cell line 0/2
Glioblastoma Disease state 0/2
Epithelial cell Cell type 0/2
HeLa Cell line 0/2
Primary Disease staging 2/0
Bone marrow Organism part 0/2
ABCB1 expression data in ATLAS

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.

Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Read more about P-glycoprotein:  Function, Structure, Mechanism of Action, Tissue Distribution, Detecting The Activity of The Transporter, History

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