Myc

Myc (c-Myc) is a regulator gene that codes for a transcription factor.

A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation and results in the formation of cancer.

A common human translocation involving Myc is t(8;14) which is critical to the development of most cases of Burkitt's Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung and stomach. Nobel laureate James D. Watson and others believe that Myc is a promising target for anti-cancer drugs.

In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin structure by regulating histone acetylation both in gene-rich regions and at sites far from any known gene.

Read more about Myc:  Discovery, Structure, Molecular Function, Myc-Nick, Animal Models, Interactions, Effects, Cancer Research

Other articles related to "myc":

Myc - Cancer Research
... Except for early response genes, Myc universally upregulates gene expression ... Genes whose expression is already signficicantly upregulated in the absence of Myc are strongly boosted in the presence of Myc where as genes whose expression is low in the absence Myc ... Inactivation of SUMO-activating enzyme (SAE1 / SAE2) in the presence of Myc hyperactivation results in mitotic catastrophe and cell death in cancer cells ...
C-myc M RNA
... C-myc mRNA is a type of mRNA that serves as a template for the MYC protein which is implicated in the rapid growth of cancer cells ... to investigate the viability of preventing cancer growth by cleaving or degrading the c-myc mRNA ...
MYCBP2
... Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the ... PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains ...
Myc-tag
... A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology ... A myc tag can be used in many different assays that require recognition by an antibody ... If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope ...
CDCA7
... This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene ... of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation ...