Myasthenia Gravis

Myasthenia gravis (from Greek μύς "muscle", ἀσθένεια "weakness", and Latin: gravis "serious"; abbreviated MG) is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatigability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors throughout neuromuscular junctions. Myasthenia is treated medically with acetylcholinesterase inhibitors or immunosuppressants, and, in selected cases, thymectomy. The disease incidence is 3–30 cases per million per year and rising as a result of increased awareness. MG must be distinguished from congenital myasthenic syndromes that can present similar symptoms but offer no response to immunosuppressive treatments.

Read more about Myasthenia Gravis:  Classification, Signs and Symptoms, Pathophysiology, Diagnosis, Management, Prognosis, Epidemiology, Notable Cases

Other articles related to "myasthenia gravis, myasthenia":

List Of Me SH Codes (C10) - MeSH C10 --- Nervous System Diseases - MeSH C10.114 --- Autoimmune Diseases of The Nervous System - MeSH C10.114.656 --- Myasthenia Gravis
... MeSH C10.114.656.300 --- myasthenia gravis, autoimmune, experimental MeSH C10.114.656.650 --- myasthenia gravis, neonatal ...
Cholinergic Crisis
... In medicine, this is seen in patients with myasthenia gravis who take too high a dose of their anticholinesterase treatment medications, or seen in some surgical cases, when too high a dose of a ... Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), which worsens the ...
Mary Broadfoot Walker - Biography
... could temporarily reverse the muscle weakness found in patients suffering from myasthenia gravis ... She had noted that the symptoms and signs of myasthenia were similar to those found in curare poisoning, and physostigmine was used as an antidote to ... The first case of myasthenia gravis successfully treated with physostigmine was published in the Lancet in June 1934 ...
Neuromuscular Junction - Diseases - Autoimmune - Myasthenia Gravis
... Myasthenia gravis is an autoimmune disorder where the body makes antibodies against either the acetylcholine receptor (AchR) (in 80% of cases), or against postsynaptic muscle-specific kinase (MuSK) (0–10% of ... In seronegative myasthenia gravis low density lipoprotein receptor-related protein 4 is targeted by IgG1, which acts as a competitive inhibitor of its ligand, preventing the ligand from ... It is not known if seronegative myasthenia gravis will respond to standard therapies ...
Myasthenia Gravis - Notable Cases
... amongst the three top players in the world and gave up professional chess to recover from myasthenia gravis during the 1980s ... of Winnie-the-Pooh ) and the person on whom Christopher Robin was based, lived with myasthenia gravis for several years before his death in 1996 ... Static died in 2008 as a result of complications stemming from plasmapheresis treatment for myasthenia gravis Roger Smith (actor), American actor famous for his role in "77 Sunset Strip" and as ...