MHC Class II


MHC Class II

MHC (major histocompatibility complex) Class II molecules are found only on antigen-presenting cells and lymphocytes.

The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in class I); hence, the MHC class II-dependent pathway of antigen presentation is called the endocytic or exogenous pathway.

Loading of MHC class II occurs by phagocytosis; extracellular proteins are endocytosed, ingested in lysosomes, and created by the class II MHC molecule prior to the molecule's migration to the cellular membrane.

Read more about MHC Class IIStructure, Reaction To Bacteria, Synthesis, Genes

Other articles related to "ii, mhc class ii, class, mhc, class ii":

... Identifiers Symbols CD74 DHLAG HLADG II Ia-GAMMA External IDs OMIM 142790 MGI 96534 HomoloGene 3209 ChEMBL 4692 GeneCards CD74 Gene Gene Ontology Molecular ... The invariant chain (Abbreviated Ii) is a polypeptide involved in the formation and transport of MHC class II protein ...
Class - Transportation
... Travel class, a quality of accommodation on public transport Class (locomotive), a single design of a locomotive as assigned by the railroad Classification ...
CD74 - Function
... The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway ... The invariant chain also facilitates MHC class II's export from the ER in a vesicle ... called CLIP which blocks peptide binding until HLA-DM binds to MHC II, releasing CLIP and allowing other peptides to bind ...
Toxic Shock Syndrome Toxin - Mechanism - Binding Site
... TSST-1 binds primarily to the alpha-chain of class II MHC exclusively through a low-affinity (or generic) binding site on the SAG N-terminal domain ... This is opposed to other super antigens (SAGs) such as DEA and SEE, that bind to class II MHC through the low-affinity site, and to the beta-chain through a high-affinity site ... MHC-binding by TSST-1 is partially peptide-dependent ...

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