Manko may refer to:
- Manko (poet), an Edo period Japanese poet
- Lake Man (Japanese: Manko), a wetland in Naha, Okinawa
- Kurenai Manko (紅萬子), a Japanese actress
- Manko Hime (萬子媛), princess who built the Yūtoku Inari Shrine
- Japanese slang for vagina or, in the verb form, to fuck (omanko suru)
- Manco, a character in the film For a Few Dollars More
- Manco Cápac, a figure of Inca mythology
- Manco Inca Yupanqui, 16th century Inca ruler