Similar to many other cancers, lung cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Oncogenes are believed to make people more susceptible to cancer. Proto-oncogenes are believed to turn into oncogenes when exposed to particular carcinogens. Mutations in the K-ras proto-oncogene are responsible for 10–30% of lung adenocarcinomas. The epidermal growth factor receptor (EGFR) regulates cell proliferation, apoptosis, angiogenesis, and tumor invasion. Mutations and amplification of EGFR are common in non-small-cell lung cancer and provide the basis for treatment with EGFR-inhibitors. Her2/neu is affected less frequently. Chromosomal damage can lead to loss of heterozygosity. This can cause inactivation of tumor suppressor genes. Damage to chromosomes 3p, 5q, 13q, and 17p are particularly common in small-cell lung carcinoma. The p53 tumor suppressor gene, located on chromosome 17p, is affected in 60-75% of cases. Other genes that are often mutated or amplified are c-MET, NKX2-1, LKB1, PIK3CA, and BRAF.
Read more about this topic: Lung Cancer
Other articles related to "pathogenesis":
... The pathogenesis of PMF is complicated, but involves two main routes - an immunological route, and a mechanical route ... that ensues as an effect of this, as well as reduced motility of cells, is fundamental to the pathogenesis of pneumoconiosis and the accompanying inflammation, fibrosis, and emphysema ... There are also some mechanical factors involved in the pathogenesis of Complex Pneumoconiosis that should be considered ...
... Although the exact pathogenesis is poorly understood, serum sickness-like reactions are thought to originate from an abnormal inflammatory reaction that occurs in response to defective metabolism of drug ...
The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent. The word comes from the Greek pathos, "disease", and genesis, "creation".
Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown.
Most diseases are caused by multiple pathogenetical processes together. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression).
Often, a potential etiology is identified by epidemiological observations before a pathological link can be drawn between the cause and the disease.
... than Htt) have since been characterised, thus elucidating a possible role for this protein in HD pathogenesis ... that this indicated HAP1 in pre-aggregate related HD pathogenesis ... The role of HAP1 in HD pathogenesis may involve aberration of cell cycle processes, as high immunostaining of HAP1 during the cell cycle has been observed ...