LRRK2

LRRK2

Identifiers Symbols LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2 External IDs OMIM: 609007 MGI: 1913975 HomoloGene: 18982 ChEMBL: 1075104 GeneCards: LRRK2 Gene EC number 2.7.11.1

Gene Ontology
Molecular function GTPase activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
GTPase activator activity
protein binding
ATP binding
GTP binding
tubulin binding
Rho GTPase binding
GTP-dependent protein kinase activity
identical protein binding
protein homodimerization activity
ion channel binding
Cellular component cytoplasm
mitochondrion
trans-Golgi network
plasma membrane
synaptic vesicle
external side of mitochondrial outer membrane
dendrite cytoplasm
neuron projection
neuronal cell body
membrane raft
Biological process MAPK cascade
activation of MAPKK activity
activation of MAPK activity
positive regulation of protein phosphorylation
GTP catabolic process
autophagy
response to oxidative stress
small GTPase mediated signal transduction
negative regulation of neuroblast proliferation
neuromuscular junction development
determination of adult lifespan
positive regulation of autophagy
positive regulation of cell death
negative regulation of neuron maturation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
olfactory bulb development
tangential migration from the subventricular zone to the olfactory bulb
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of GTPase activity
regulation of kidney size
exploration behavior
regulation of locomotion
regulation of membrane potential
positive regulation of programmed cell death
positive regulation of GTPase activity
protein autophosphorylation
intracellular distribution of mitochondria
positive regulation of dopamine receptor signaling pathway
negative regulation of dendritic spine morphogenesis
neuron death
negative regulation of branching morphogenesis of a nerve
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 120892 66725 Ensembl ENSG00000188906 ENSMUSG00000036273 UniProt Q5S007 Q5S006 RefSeq (mRNA) NM_198578 NM_025730 RefSeq (protein) NP_940980 NP_080006 Location (UCSC) Chr 12:
40.59 – 40.76 Mb Chr 15:
91.67 – 91.82 Mb PubMed search

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling), is an enzyme that in humans is encoded by the PARK8 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

Read more about LRRK2:  Function, Clinical Significance

Other articles related to "lrrk2":

LRRK2 - Clinical Significance
... The Gly2019Ser mutation in LRRK2 is a relatively common cause of familial Parkinson's Disease in Caucasians ... Gly2019Ser mutation is one of a small number of LRRK2 mutations proven to cause Parkinson's disease ... studies have found an association between LRRK2 and Crohn's disease as well as with Parkinson's disease, suggesting that the two diseases share ...