LRRK2

LRRK2

Identifiers Symbols LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2 External IDs OMIM: 609007 MGI: 1913975 HomoloGene: 18982 ChEMBL: 1075104 GeneCards: LRRK2 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• GTPase activity • protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase activity • GTPase activator activity • protein binding • ATP binding • GTP binding • tubulin binding • Rho GTPase binding • GTP-dependent protein kinase activity • identical protein binding • protein homodimerization activity • ion channel binding
Cellular component	• cytoplasm • mitochondrion • trans-Golgi network • plasma membrane • synaptic vesicle • external side of mitochondrial outer membrane • dendrite cytoplasm • neuron projection • neuronal cell body • membrane raft
Biological process	• MAPK cascade • activation of MAPKK activity • activation of MAPK activity • positive regulation of protein phosphorylation • GTP catabolic process • autophagy • response to oxidative stress • small GTPase mediated signal transduction • negative regulation of neuroblast proliferation • neuromuscular junction development • determination of adult lifespan • positive regulation of autophagy • positive regulation of cell death • negative regulation of neuron maturation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • olfactory bulb development • tangential migration from the subventricular zone to the olfactory bulb • positive regulation of protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of GTPase activity • regulation of kidney size • exploration behavior • regulation of locomotion • regulation of membrane potential • positive regulation of programmed cell death • positive regulation of GTPase activity • protein autophosphorylation • intracellular distribution of mitochondria • positive regulation of dopamine receptor signaling pathway • negative regulation of dendritic spine morphogenesis • neuron death • negative regulation of branching morphogenesis of a nerve
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 120892 66725 Ensembl ENSG00000188906 ENSMUSG00000036273 UniProt Q5S007 Q5S006 RefSeq (mRNA) NM_198578 NM_025730 RefSeq (protein) NP_940980 NP_080006 Location (UCSC) Chr 12:
40.59 – 40.76 Mb Chr 15:
91.67 – 91.82 Mb PubMed search

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling), is an enzyme that in humans is encoded by the PARK8 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.