Low Density Lipoprotein Receptor-related Protein 8

Low Density Lipoprotein Receptor-related Protein 8

Identifiers Symbols LRP8; APOER2; HSZ75190; LRP-8; MCI1 External IDs OMIM: 602600 MGI: 1340044 HomoloGene: 31250 GeneCards: LRP8 Gene

Gene Ontology
Molecular function	• transmembrane signaling receptor activity • calcium ion binding • protein binding • very-low-density lipoprotein particle receptor activity • apolipoprotein binding • reelin receptor activity
Cellular component	• extracellular region • plasma membrane • caveola • integral to membrane
Biological process	• negative regulation of transcription from RNA polymerase II promoter • proteolysis • lipid metabolic process • endocytosis • signal transduction • blood coagulation • cytokine-mediated signaling pathway • ammon gyrus development • layer formation in cerebral cortex • positive regulation of CREB transcription factor activity • reelin-mediated signaling pathway • positive regulation of peptidyl-tyrosine phosphorylation • regulation of synaptic transmission • positive regulation of dendritic spine morphogenesis • positive regulation of protein tyrosine kinase activity • positive regulation of dendrite development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7804 16975 Ensembl ENSG00000157193 ENSMUSG00000028613 UniProt Q14114 Q924X6 RefSeq (mRNA) NM_001018054.2 NM_001080926.1 RefSeq (protein) NP_001018064.1 NP_001074395.1 Location (UCSC) Chr 1:
53.71 – 53.79 Mb Chr 4:
107.8 – 107.88 Mb PubMed search

Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.