The Cancer Research UK London Research Institute (LRI) is a biological research facility whose aim is to conduct research into the basic biology of cancer. The LRI houses 46 research groups based at two locations: Lincoln's Inn Fields (LIF) laboratories in central London, and Clare Hall (CH) laboratories on London's outskirts at South Mimms, Hertfordshire.
The LRI has its origins as the principal research facilities of the Imperial Cancer Research Fund which was founded in 1902 - the first specialist cancer research charity in the United Kingdom. In 2002, the Imperial Cancer Research Fund and the Cancer Research Campaign merged to form Cancer Research UK, the largest cancer charity in Europe with an annual scientific spend of £257 million (in 2005/06). The LRI is the largest core-funded institute in Cancer Research UK's portfolio.
The LRI has an international reputation for cancer research. Themes of research are signal transduction (biology of tissues and organs, and molecular cell biology) and genome integrity (cell cycle and chromosomes and DNA repair). Eleven of the scientific staff are Fellows of the Royal Society and two have received knighthoods and two are Nobel Laureates.
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