Lamin - A, B, and C Types

A, B, and C Types

In animal cells, there are A- and B-type lamins, which differ in their length and pI. Human cells have three differentially regulated genes.

  • B-type lamins are present in every cell. B type lamins, B1 and B2, are expressed from the LMNB1 and LMNB2 genes on 5q23 and 19q13, respectively.
  • A-type lamins are expressed only following gastrulation. Lamin A and C are the most common A-type lamins and are splice variants of the LMNA gene found at 1q21.
  • C-type lamins are also subject to tissue-specific expression.

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