Isocitrate Dehydrogenase

Isocitrate dehydrogenase (EC 1.1.1.42) and (EC 1.1.1.41), also known as IDH, is an enzyme that participates in the citric acid cycle. It catalyzes the third step of the cycle: the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2 while converting NAD+ to NADH. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. Another isoform of the enzyme catalyzes the same reaction, however this reaction is unrelated to the citric acid cycle, is carried out in the cytosol as well as the mitochondrion and peroxisome and uses NADP+ as a cofactor instead of NAD+.

Read more about Isocitrate Dehydrogenase:  Structure, Regulation, Catalytic Mechanism, Clinical Significance

Other articles related to "isocitrate dehydrogenase, isocitrate":

Isocitrate Dehydrogenase - Clinical Significance
... Specific mutations in the isocitrate dehydrogenase gene IDH1 have been found in several brain tumors including astrocytoma, oligodendroglioma and glioblastoma multiforme ...
Isocitrate Lyase - Mechanism
... During catalysis, isocitrate is deprotonated, and an aldol cleavage results in the release of succinate and glyoxylate ... ICL competes with isocitrate dehydrogenase, an enzyme found in the TCA cycle, for isocitrate processing ... Flux through these enzymes is controlled by phosphorylation of isocitrate dehydrogenase, which has a much higher affinity for isocitrate as compared to ICL ...
Idh1 - Isozymes - NAD+ Dependent
... The isocitrate dehydrogenase 3 isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit isocitrate dehydrogenase 3 (NAD+) alpha Identifiers Symbol IDH3A. 15 q25.1-25.2 isocitrate dehydrogenase 3 (NAD+) beta Identifiers Symbol IDH3B Entrez 3420 HUGO 5385 OMIM 604526 RefSeq NM_174855 UniProt O43837 Other data EC. 20 p13 isocitrate dehydrogenase 3 (NAD+) gamma Identifiers Symbol IDH3G Entrez 3421 HUGO 5386 OMIM 300089 RefSeq NM_174869 UniProt P51553 Other data EC number 1.1.1.41 ...
(isocitrate Dehydrogenase (NADP+)) Kinase
... reaction ATP + ADP + phosphate Thus, the two substrates of this enzyme are ATP and isocitrate dehydrogenase (NADP+), whereas its two products are ADP ...