Insulin Receptor

Insulin Receptor

Identifiers Symbols INSR; CD220; HHF5 External IDs OMIM: 147670 MGI: 96575 HomoloGene: 20090 ChEMBL: 1981 GeneCards: INSR Gene EC number

Gene Ontology
Molecular function protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
insulin-activated receptor activity
insulin-like growth factor receptor binding
protein binding
ATP binding
GTP binding
protein phosphatase binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
protein complex binding
SH2 domain binding
3-phosphoinositide-dependent protein kinase binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
PTB domain binding
Cellular component nucleus
plasma membrane
integral to plasma membrane
insulin receptor complex
endosome membrane
Biological process activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
carbohydrate metabolic process
regulation of transcription, DNA-dependent
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
response to glucose stimulus
response to manganese ion
regulation of hydrogen peroxide metabolic process
positive regulation of glycoprotein biosynthetic process
negative regulation of gene expression
response to activity
peptidyl-tyrosine phosphorylation
transformation of host cell by virus
signal transduction by phosphorylation
male sex determination
positive regulation of cell migration
exocrine pancreas development
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol stimulus
negative regulation of transporter activity
cellular response to insulin stimulus
response to vitamin D
response to testosterone stimulus
response to tumor necrosis factor
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolysis
positive regulation of mitosis
regulation of embryonic development
positive regulation of glucose import
protein autophosphorylation
positive regulation of developmental growth
protein heterotetramerization
response to glucocorticoid stimulus
positive regulation of protein kinase B signaling cascade
positive regulation of respiratory burst
cellular response to growth factor stimulus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3643 16337 Ensembl ENSG00000171105 ENSMUSG00000005534 UniProt P06213 P15208 RefSeq (mRNA) NM_000208.2 NM_010568.2 RefSeq (protein) NP_000199.2 NP_034698.2 Location (UCSC) Chr 19:
7.11 – 7.29 Mb Chr 8:
3.15 – 3.28 Mb PubMed search

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

Read more about Insulin Receptor:  Structure, Ligand Binding, Biological Significance, Pathology, Regulation of Gene Expression, Stimulation of Glycogen Synthesis, Degradation of Insulin, Interactions

Other articles related to "insulin receptor, insulin, receptors, receptor":

Kenneth Chiacchia - Scholarly Articles
... Quantitation of the class I disulfides of the insulin receptor ... Reoxidation of the class I disulfides of the rat adipocyte insulin receptor is dependent upon the presence of insulin the class I disulfide of the insulin receptor is extracellular ... transmembrane orientation of the hepatic glycoprotein receptors ...
... Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene ... IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites ... The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. ...
Insulin Receptor - Interactions
... Insulin receptor has been shown to interact with Ectonucleotide pyrophosphatase/phosphodiesterase 1, PTPN11, GRB10, GRB7, PRKCD, IRS1, SH2B1 and Mothers against decapentaplegic homolog 2 ...
... Molecular function • protein tyrosine phosphatase activity • insulin receptor binding • protein binding • zinc ion binding • enzyme binding • protein kinase ... PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes ...
... actin binding • SH3/SH2 adaptor activity • insulin receptor binding • protein binding • cytoskeletal protein binding • protein kinase binding Cellular component ...

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