HDC is an acronym that can stand for:
- Hyundai Development Company, a Engineering & Construction Company in South Korea
- The Home Depot Center, a 27,000-seat soccer stadium in Carson, CA that serves as home to the Los Angeles Galaxy and Chivas USA
- The Human Defense Corps, a fictional branch of the United States Armed Forces appearing in stories published by DC Comics
- Henry Draper Catalogue, a star catalogue
- Holder in due course, a term used in law
- Herräng Dance Camp, an annual international dance camp in Sweden
- half double crochet
- Technology and computing
- /dev/hdc, the master device on the second ADA channel
- High-Definition Coding, an audio compression codec
- Handle of Device Context (hDC), Handle for Device Context in GDI (Windows Programming)
- Hard Disk controller, a component of the hard disk drive
- half.com, a fixed price site owned by eBay - the "DC" standing for "dot com"
- hackers.com, an old and now extinguished anonymous BBS about technologies - the "DC" standing for "dot com"
- Biology and Science
- Histidine decarboxylase, the enzyme that catalyzes the reaction which produces histamine from histidine
- Heat-denatured Casein, used with phosphate buffered saline (PBS) as a blocking buffer
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