Filamin

FBLIM1
... GeneCards FBLIM1 Gene Gene Ontology Molecular function • zinc ion binding • filamin binding • metal ion binding Cellular component • stress fiber ... This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains ...

FLNC (gene) - Function
... This gene encodes one of three related filamin genes, specifically gamma filamin ... These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins ... Three functional domains exist in filamin an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain ...

Larsen Syndrome - Causes - Mutations in Gene Encoding Filamin B
... Filamins are cytoplasmic proteins that regulate the structure and activity of the cytoskeleton ... Filamin B has been found to be expressed in human growth plate chondrocytes ... has found that Larsen syndrome is caused by missense mutations in the gene that codes for filamin B ...