Corepressor

In the field of molecular biology, a corepressor is a substance that inhibits the expression of genes. In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors.

A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene promoter (a sequence of DNA adjacent to the regulated gene), thereby blocking transcription of that gene.

Other articles related to "corepressor, corepressors":

BCOR
... HomoloGene 9809 GeneCards BCOR Gene Gene Ontology Molecular function • transcription corepressor activity • ubiquitin-protein ligase activity • protein binding ... The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for ...
DRAP1
... transcription factor activity • transcription corepressor activity • transcription factor binding • sequence-specific DNA binding • protein heterodimerization activity Cellular component ... The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression ... The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex ...
Transcription Coregulators - Histone Acyltransferases - Nuclear Receptor Corepressors
... Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where ... with class II histone deacetylases) LCoR (ligand-dependent corepressor) Nuclear receptor CO-Repressor (NCOR) NCOR1 (NCOR1) NCOR2 (NCOR2)/SMRT (Silencing Mediator (co-repressor) for Retinoid and ...
Corepressor - Function - Eukaryotes
... In eukaryotes, a corepressor is a protein that binds to transcription factors ... In the absence of corepressors and in the presence of coactivators, transcription factors upregulate gene expression ... Coactivators and corepressors compete for the same binding sites on transcription factors ...