Cis-natural Antisense Transcript
Natural antisense transcripts (NATs) are a group of RNAs encoded within a cell that have transcript complementarity to other RNA transcripts. They have been identified in multiple eukaryotes, including humans, mice, yeast and Arabidopsis thaliana. This class of RNAs includes both protein-coding and non-coding RNAs. Current evidence has suggested a variety of regulatory roles for NATs, such as RNA interference (RNAi), alternative splicing, genomic imprinting, and X-chromosome inactivation. NATs are broadly grouped into two categories based on whether they act in cis or in trans. Trans-NATs are transcribed from a different location than their targets and usually have complementarity to multiple transcripts with some mismatches. MicroRNAs (miRNA) are an example of trans-NATs that can target multiple transcripts with a few mismatches. Cis-natural antisense transcripts (cis-NATs) on the other hand are transcribed from the same genomic locus as their target but from the opposite DNA strand and form perfect pairs.
Read more about Cis-natural Antisense Transcript: Orientation of Cis-NATs, Identification Approach, Mechanisms, Importance, Cis-NATs and Disease
Other articles related to "antisense, transcript, antisense transcript, antisense transcripts, transcripts":
... Intronic antisense ncRNAs with expression correlated to the degree of tumor differentiation in prostate cancer samples have also been reported (Reis 2004) ... for myocardial infarction mapped to a long ncRNA, MIAT (myocardial infarction associated transcript) (Ishii 2006) ... form of ZFAT and the promoter of an antisense transcript increases the expression of ZFAT not through increasing the mRNA stability, but rather by repressing the expression of the antisense transcript (Shirasawa 2004) ...
... Antisense transcription might contribute to disease through chromosomal changes that result in the production of aberrant antisense transcripts ... It is likely that aberrant antisense RNA transcripts resulting from this transcriptional noise may cause stochastic methylation of CpG islands associated with oncogenes and tumor suppressor genes ... By looking at upregulated antisense transcripts in tumor cells, researchers and look for more candidate tumor suppressor genes ...