Chromatin Remodeling

Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, i.e., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. Besides actively regulating gene expression, dynamic remodeling of chromatin imparts an epigenetic regulatory role in several key biological processes, e.g., DNA replication and repair; apoptosis; chromosome segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.

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Other articles related to "chromatin remodeling, remodeling, chromatin":

Epigenetics - Mechanisms - DNA Methylation and Chromatin Remodeling
... One way that genes are regulated is through the remodeling of chromatin ... Chromatin is the complex of DNA and the histone proteins with which it associates ... Chromatin remodeling is accomplished through two main mechanisms The first way is post translational modification of the amino acids that make up histone proteins ...
Imitation SWI
... fruit fly), is the first ATPase subunit which has been isolated in the ISWI chromatin remodeling family ... high level of similarity to the SWI/SNF chromatin remodeling family in the ATPase domain ... ISWI can interact with several proteins giving three different chromatin-remodeling complexes in Drosophila melanogaster NURF(nucleosome remodeling factor), CHRAC (c ...
Epigenomics - Epigenetics - Histone Modification
... is coiled into protein-DNA complexes called chromatin ... which are the most prevalent type of protein found in chromatin, function to condense the DNA the net positive charge on histones facilitates their bonding with DNA, which is negatively charged ... The basic and repeating units of chromatin, nucleosomes, consist of an octamer of histone proteins (H2A, H2B, H3 and H4) and a 146 bp length of DNA wrapped around it ...
Deoxyribonucleic Acid - Chemical Modifications and Altered DNA Packaging - Base Modifications and DNA Packaging
... Further information DNA methylation, Chromatin remodeling The expression of genes is influenced by how the DNA is packaged in chromosomes, in a structure called chromatin ... by covalent modifications of the histone protein core around which DNA is wrapped in the chromatin structure or else by remodeling carried out by ... DNA methylation and histone modification, so they can coordinately affect chromatin and gene expression ...